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Tomas Lindahl, Paul Modrich and Aziz Sancar jointly win the Nobel Prize for chemistry
Their work could be beneficial in finding new cancer treatments
The 2015 Nobel Prize for chemistry has been jointly awarded to three scientists for their “mechanistic studies of DNA repair,” the Royal Swedish Academy of Sciences announced Wednesday.
Tomas Lindahl, Paul Modrich and Aziz Sancar won “for having mapped, at a molecular level, how cells repair damaged DNA and safeguard the genetic information.”
“Their work has provided fundamental knowledge of how a living cell functions and is, for instance, used for the development of new cancer treatments,” the academy said.
The organization tweeted graphics explaining the scientists’ work.
Lindahl, a Swedish scientist, showed that “DNA decays at a rate that ought to have made the development of life on Earth impossible,” the academy said.
“This insight led him to discover a molecular machinery, base excision repair, which constantly counteracts the collapse of our DNA.”
Modrich, an American, showed how a cell corrects errors that occur when DNA is replicated during cell division.
“This mechanism, mismatch repair, reduces the error frequency during DNA replication by about a thousandfold,” the academy said.
“Congenital defects in mismatch repair are known, for example, to cause a hereditary variant of colon cancer.”
Sancar, a U.S. and Turkish citizen, mapped nucleotide excision repair – the mechanism that cells use to repair UV damage to DNA, the academy said.
“People born with defects in this repair system will develop skin cancer if they are exposed to sunlight, it said.
Last year, two Americans and a German won the chemistry prize for their work on optical microscopy, which opened up our understanding of molecules by allowing us to see how they work close up.
The winners were Eric Betzig, Stefan W. Hell and William E. Moerner.
Since 1901, the committee has handed out the Nobel Prize in chemistry 107 times. In certain years, mainly during World Wars I and II, no prize in chemistry was awarded.
The youngest recipient was Frederic Joliot, who won in 1935 at the age of 35. The oldest chemistry laureate was John B. Fenn, who was 85 when he received the prize in 2002.
Frederic Sanger was the only scientist to win the chemistry prize twice, for his work related to the structure of proteins and DNA.
There is a fine line between the science of chemistry and the fields of physics and biology.
Famed scientist Marie Curie of France, for example, won Nobel honors for her work in radiophysics in 1903 and again in 1911 for discoveries in radiochemistry.
This week, Nobel prizes have already been awarded in medicine and physics.
The committee also will announce prizes in literature, peace and economics in the coming days.
Swedish industrialist Alfred Nobel created the prizes in 1895 to honor work in physics, chemistry, literature and peace. The economics prize, established in 1968 as a memorial to Nobel, was first awarded in 1969.
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