No one in NFL history has thrown for more yards and touchdowns than Peyton Manning. The quarterback won two Super Bowl titles: one with the Denver Broncos in 2016, and one with the Indianapolis Colts in 2007. See more moments from Manning's historic career.
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Before entering the NFL, Manning played four years at the University of Tennessee and was a consensus All-American in 1997. He still holds many of the school's passing records.
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In 1998, the Colts selected Manning with the No. 1 overall pick in the NFL Draft.
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Manning scrambles into the end zone for a touchdown in 2000.
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Manning, left, and New England quarterback Tom Brady greet each other on the field after the AFC Championship game in 2004. Brady's Patriots won that game to advance to the Super Bowl. During their careers, Manning and Brady have played each other 17 times -- five times in the playoffs.
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Manning gives an interview after a 2004 game in which he set a new single-season record for touchdowns (49). He'd go on to break that record again in 2013.
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Manning talks to the media after signing a deal with a sports memorabilia company in 2005. Manning's "everyman" persona has also made him a popular pitchman for brands such as Gatorade, Papa John's and Nationwide.
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Manning signs autographs for fans during training camp in 2005.
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Manning has his college jersey retired before a Tennessee game in 2005.
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Manning, right, shoots a Reebok commercial in 2006 with his brother Eli and their father, Archie. Archie was an NFL quarterback from 1971-1984, and Eli has won two Super Bowls as quarterback of the New York Giants.
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Manning stands on the sidelines with his Colts teammates during a game in 2006.
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Manning holds the Vince Lombardi Trophy after the Colts won Super Bowl XLI in 2007. Manning was named the game's Most Valuable Player as the Colts defeated the Chicago Bears 29-17.
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Manning showed off his comedic chops in 2007 when he hosted an episode of "Saturday Night Live." In this memorable skit, he demonstrates how to break into a car.
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A Colts fan shows his support for Manning during a home game in 2007.
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Manning plays a game in San Diego in 2007. During his career, Manning has been MVP of the league five times. He has also been named to 14 Pro Bowls -- the NFL's all-star game.
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Manning walks off the field during Super Bowl XLIV in 2010. The Colts lost to the New Orleans Saints 31-17.
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Manning talks to Colts teammate Curtis Painter during a game in 2011. Manning missed the entire season after undergoing surgery for a herniated disc in his neck.
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Manning and Colts owner Jim Irsay held a news conference in 2012 to announce that the Colts would be releasing Manning after 14 seasons. The Colts had the first overall pick in the 2012 draft, and they were choosing to start over at the quarterback position. They drafted Andrew Luck one month later.
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Manning walks off the field in 2012 after his first regular-season game as a Denver Bronco. He signed a five-year deal with the team after being released by the Colts.
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Manning plays St. Louis during a preseason game in 2013.
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Manning leaves the field after the Broncos were crushed by Seattle in Super Bowl XLVIII in 2014.
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Manning and talk-show host David Letterman throw footballs at New York City cabs during a "Late Show" taping in 2014.
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Denver fans celebrate in 2014 after Manning threw his 509th career touchdown pass, breaking the NFL record held by Brett Favre.
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During a game in November, Manning acknowledges the Denver crowd after he set a new NFL record for career passing yards. Favre held the previous record (71,838).
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Manning walks off the field Sunday, February 7, after the Broncos won Super Bowl 50. Manning is the only NFL quarterback to win a Super Bowl with two different teams.
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Manning addresses the media as he announces his retirement on Monday, March 7.