Defending champion and world No. 1 Dustin Johnson was the biggest casualty of the halfway cut in the 117th US Open at Erin Hills.
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Second and third-ranked Rory McIlroy and Jason Day also made early exits as the deep fescue rough took its toll on wayward shots.
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England's Paul Casey maintained his momentum from day one to card a 71 for seven under overall and in a four-way share of the lead.
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Tommy Fleetwood was another Englishman in a share of the lead at seven under after two rounds Friday.
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American Brooks Koepka climbed into a share of the lead with rounds of 67, 70.
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Left-handed American Brian Harman completed the quartet in the lead, all searching for a first major title.
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Masters champion Sergio Garcia shot 71 to edge to three under and a tie for 18th, the highest-placed player with a major title to his name.
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Japan's Hideki Matsuyama was on target to break the major championship scoring record of 63 at seven under after 13 holes, but five pars coming home gave him a 65.
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Masters runner-up Justin Rose, the 2013 champion, was another big name heading home early from Wisconsin after ending two over.
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Two-time Masters champion Bubba Watson seems to struggle in the other majors and the left-hander and his yellow ball missed the cut at Erin Hills with rounds of 75, 73 for four over.