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Monaco, a country with a population of fewer than 40,000 people, had recorded nine cases of coronavirus before the monarch’s diagnosis was announced.
Neighboring France has been one of the worst-affected nations in Europe, confirming more than 7,600 cases and 175 deaths.
“His Serene Highness urges the people of Monaco to respect the measures of confinement and to limit contact with others to a minimum,” the palace’s statement added.
“Only the strict observance of these confinement measures will make it possible to stop the spread of the coronavirus.”
CNN’s Benjamin Berteau contributed reporting from Paris